Donna Farber discusses the development of lung-localized immune responses and the role of tissue resident memory T cells in protective immunity to respiratory viruses, in mouse models of influenza infection and in human lungs, including recent findings on the impact of age on human lung immunity.
These concepts has been discussed in the context of respiratory immunity in SARS-CoV2 infection and our studies identifying potential immune correlates of disease severity in COVID-19.
Donna Farber is the George H Humphreys, II Professor of Surgical Sciences (in Surgery) and Professor of Microbiology and Immunology at Columbia University. The focus of Dr. Farber’s research is on adaptive immunity, particularly to virus infections and how T cell differentiate and generate long-term immunological memory in diverse tissues sites.
Dr. Farber’s laboratory identified subsets of tissue-resident memory T cells in the lung that mediate protective immunity to respiratory virus infection and has led an initiative in translational immunology to dissect human immune responses in tissues throughout the body, in multiple mucosal and lymphoid tissues from individual organ donors of all ages.
Henry Mwandumba is Professor of Immunology and Infectious Diseases at the University of Malawi College of Medicine and Deputy Director of the Malawi Liverpool Wellcome Trust Clinical Research Programme (MLW) in Blantyre, Malawi. His research focuses on understanding the effects of HIV-1 infection on lung immunity and predisposition to respiratory infections, particularly tuberculosis. He is President of the Federation of African Immunological Societies (FAIS) and was awarded the 2019 Royal Society Africa Prize.