Clinical outcome upon infection with SARS-CoV-2 ranges from silent infection to lethal COVID-19. We identified autosomal-recessive or autosomal-dominant deficiencies of genes in the type I IFN circuit in 23 patients (3.5%) 17 to 77 years of age. We showed that inborn errors of TLR3- and IRF7- dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.
Qian Zhang was trained as a pediatrician, after she graduated from the Medical School of Fudan University in Shanghai. She joined Dr. Helen ’u’s lab at the NIH as a postdoc to be trained in scientific research in the field of inborn errors of immunity. In 2017, she first joined as a visiting scholar but soon as a group leader at the lab of Prof. Jean-Laurent Casanova and Laurent ’bel’s lab, and focuses her research on human genetics of respiratory viral infections.
A/PROF Jonathan Peter is a physician, specialised in internal medicine at the University of Cape Town, South Africa. In February 2016, Jonathan was registered with the HPCSA as the first adult allergologist in South Africa, and is Head of the Division of Allergology and Clinical Immunology at Groote Schuur Hospital, University of Cape Town and the Allergy and Immunology unit, UCT Lung Institute. Current clinical and research interests include: i) immune-mediated adverse drug reactions ii) urticaria and angioedema, as well as the intersection between COVID19 and immunogenomic pathways associated with Angioedema iii) primary immunodeficiencies, and iv) the aerobiology of South Africa. Jonathan has over 80 publications in high impact factor journals, and H-index of 36. His research work is supported by international and local grant funding from the NIH, EDCTP, SA NRF and MRC.