Live Webinar: Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis

Monday 22nd June 2020

Eric Vivier provides a longitudinal analysis of immune responses, including immune cell phenotyping and assessments of the soluble factors present in the blood and broncho-alveolar lavage fluid (BALF) of patients at various stages of COVID-19 severity: paucisymptomatic, pneumonia and acute respiratory distress syndrome (ARDS).

He reports an increase in soluble C5a levels proportional to COVID-19 severity and high levels of C5aR1 expression in blood and pulmonary myeloid cells, supporting a role for the C5a-C5aR1 axis in the pathophysiology of ARDS.

Anti-C5aR1 therapeutic monoclonal antibodies (mAbs) prevented C5a-mediated human myeloid cell recruitment and activation, and inhibited acute lung injury (ALI) in human C5aR1 knockin mice.

These results support C5a-C5aR1 axis blockade as a means of limiting myeloid cell infiltration in damaged organs and preventing the excessive lung inflammation and endothelialitis associated with ARDS in COVID-19 patients.

Join the webinar: IUIS-Frontiers Webinar Series on COVID-19


Event Details


Upcoming Events

Live Webinar: Qian Zhang “Inborn errors of type I IFN immunity in patients with life-threatening COVID-19”

Monday 19th April 2021

2021 International Day of Immunology

Thursday 29th April 2021

Novel Concepts in Innate Immunity

Wednesday 26th May 2021

CSI-SCI2021 Virtual Conference

Monday 31st May 2021Canadian Society for Immunology

FOCIS 2021 virtual annual meeting / Federation of Clinical Immunology Societies

Tuesday 8th June 2021

AAI Introductory Course in Immunology

Monday 12th July 2021

AAI Advanced Course in Immunology

Sunday 25th July 2021

FAIS 2021 – 11th African Congress of Immunology

Sunday 1st August 2021 at Bingu International Conference Center

IVIS 2022

Sunday 8th August 2021