Overview
The talk will cover both innate and adaptive immune aspects potentially driving pathology following SARS-CoV-2 infection. Applying their immune monitoring experience to large patient cohorts hospitalized at Mount Sinai in New York during the COVID-19 epidemic, Sacha Gnjatic and his team investigated cytokine and antibody profiles. They found that levels of IL-6, TNF-alpha, and antiviral immunoglobulins are helpful in predicting severity and survival outcome, and may be useful to stratify patients and guide tailored therapies.
Speakers
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Sacha Gnjatic
Sacha Gnjatic is an associate professor and the co-director of the Human Immune Monitoring Center at Mount Sinai. After obtaining his PhD evaluating p53 as a tumor antigen in Paris, he trained with Dr. Lloyd Old at the Ludwig Institute in New York where he studied T cell and antibody responses specific to NY-ESO-1, in particular for antigen presentation and tolerance mechanisms. As a tumor immunologist, he specializes in studying immune correlates, both circulating and tissue-based, to define biomarkers of immunotherapies from human clinical trials.
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Miriam Merad
Miriam Merad, M.D.; Ph.D. is the Mount Sinai Chair professor in Cancer Immunology and the Director of the Precision Immunology Institute at Mount Sinai School of Medicine in New York. Dr. Merad also co-Directs, the Cancer Immunology program at The Mount Sinai Tisch Cancer Institute and is the Director of the Mount Sinai Human Immune Monitoring Center (HIMC).
Miriam Merad is the Vice-President of IUIS.
Webinar Details
Categories: COVID-19