Since this Sub-Committee has not addressed MHC/HLA nomenclature for several decades, the name of the Sub-Committee has been changed to “T-cell Receptor and Immunoglobulin Nomenclature Sub-Committee” (or “TR-IG NSC”).
Co-Chairs
Felix Breden (Canada), 2013
Email: breden@sfu.ca
John Hammond (UK), 2020
Email: john.hammond@pirbright.ac.uk
Members
- Eva Bengtén (USA) 2006
- Salvatrice Ciccarese (Italy) 2007
- Deborah Dunn‐Walters (UK) 2006
- Jean‐Pol Frippiat (France) 2006
- Véronique Giudicelli (France) 2014
- Sofia Kossida (France) 2014
- Ramit Mehr (Israel) 2017
- John Schwartz (UK) 2020
- Jamie Scott (Canada) 2013
- Corey T. Watson (USA) 2013
The T-cell Receptor and Immunoglobulin Nomenclature Sub-Committee adopted Terms of Reference in Spring 2022, outlining a democratic and transparent governance structure. The following description of the Sub-Committee’s goals, structure, and processes will be revised as the quantity and types of data available for understanding T-cell receptor and immunoglobulin germline gene polymorphisms change and as the Sub-Committee strives to best serve the immunogenetics community.
Mission:
In continuing the pioneering work of Dr. Marie-Paule Lefranc, the T-Cell Receptor and Immunoglobulin Nomenclature Sub-Committee is responsible for validating, approving, and assigning names to newly discovered T-cell receptor (TR) and immunoglobulin (IG) germline genes, following the principles of the IMGT™ information system insofar as possible. This Sub-Committee is also responsible for coordinating the biocuration of these genes in the appropriate germline gene databases.
Values:
The T-cell Receptor and Immunoglobulin Nomenclature Sub-Committee will practice in its governance and its partnerships:
- Excellence and professionalism
- Inclusivity and diversity
- Transparency and integrity
- Innovation and sustainability
Terms of Reference
Click here to access the terms of reference for this Sub-committee
Reports to IUIS.
You will find information about the history of the Sub-Committee since its creation and annual reports through the 17th International Congress of Immunology in 2019 here:
2020-2021 Sub-committee Report
IUIS NOM IMGT-NC report table 2017-2022
To contact TR-IG NSC, send an email to: tr-ig-subcomm@iuis.org
TR-IG Nomenclature Review Committee (formerly IMGT-NC Reports Review Committee)
Mission:
The TR-IG Nomenclature Review Committee was established as an elected body by the IUIS TR-IG Nomenclature Sub-Committee in October 2022. TR-IG Nomenclature Review Committee has been tasked with developing procedures for evaluating, naming, and reporting new germline genes encoding T-cell receptors (TR) and immunoglobulins (IG). The IMGT-NC Reports Review Committee previously performed this function.
Members:
Andrew Collins (University of New South Wales; webpage) 2022
Elisa Rosati Scalchi (GSK; Linkedin) 2022
Corey Watson (University of Louisville; webpage) 2022
Henk-Jan van den Ham (ENPICOM;LinkedIn) 2022
Luc Teyton (Scripps Research; webpage) 2022
Yana Safonova (Johns Hopkins; webpage) 2022
To contact TR-IG Nomenclature Review Committee, send an email to tr-ig-nrc@iuis.org.
Germline gene submission for review and approval:
Scientists submit sequences for new IG and TR variable (V), diversity (D), joining (J) and constant (C) genes and alleles to the TR-IG Review Committee. Working with the submitters, members of this Review Committee review and approve sequences and names, based on specific data-driven criteria and review processes. Validated IG and TR germline gene sequences and their names are passed to partner databases for curation and inclusion in germline gene/allele sets.
Note: The Nomenclature Review Committee has developed policies for evaluating and naming of submissions of novel TR and IG genes and alleles, avaliable here. Please contact us at tr-ig-nrc@iuis.org if you would like to submit sequences for review and approval.
Inferred Allele Review Committee
IG and TR germline V gene sequences can also be deduced from next-generation sequencing data from a B- or T-cell receptor repertoire. The Inferred Allele Review Committee (IARC) is a committee of the Adaptive Immune Receptor Repertoire (AIRR) Community Committee of The Antibody Society whose mission is to validate human IG and TR germline V gene allelic sequences that have been inferred from next-generation sequencing data. Criteria required for an inferred V allele to be considered for validation include (1) deposition of the repertoire from which the inference was made in the NCBI or ENA and in a peer-reviewed publication, (2) the complete V coding region, (3) inferences made with a validated and publicly available tool published in a peer-reviewed publication. IARC works with the TR-IG Nomenclature Review Committee to validate gene sequences and names.
Guidelines for submitting inferred allele sequences to the IARC through OGRDB can be found here.
Mats Ohlin (Sweden), Chair
Email: mats.ohlin@immun.lth.se
Current public databases containing IG and TR germline-gene sequences and reference sets.