Immunoglobulins (IG), T cell Receptors (TR) and Major Histocompatibility (MH) Nomenclature Sub-Committee


Chair

Marie‐Paule Lefranc (France), Founding and Life Member 1989

Email: marie-paule.lefranc@outlook.fr

Deputy Chair

Fumihiko Matsuda (Japan), Founding and Life Member 1989

Email: fumi@genome.med.kyoto-u.ac.jp


Members
  • Cynthia L. Baldwin (USA) 2006
  • Eva Bengtén (USA) 2006
  • Pierre Boudinot (France) 2006
  • Felix Breden (Canada) 2013
  • Salvatrice Ciccarese (Italy) 2007
  • Mike Criscitiello (USA) 2020
  • Deborah Dunn‐Walters (UK) 2006
  • Jean‐Pol Frippiat (France) 2006
  • Véronique Giudicelli (France) 2014
  • John Hammond (UK) 2020
  • Evelyne Jouvin-Marche (France) 2006
  • Sofia Kossida (France) 2014
  • Ramit Mehr (Israel) 2017
  • Serge Muyldermans (Belgium) 2006
  • John Schwartz (UK) 2020
  • Jamie Scott (Canada) 2013
  • Bettina Wagner (USA) 2006
  • Corey T. Watson (USA) 2013

Founding and Life Members

  • Max Cooper (USA), Founding and Life Member 1989
  • Tasuku Honjo (Japan), Founding and Life Member 1989, Nobel Prize 2018
  • Leroy Hood (USA), Founding and Life Member 1989
  • Gérard Lefranc (France), Founding and Life Member 1989
  • Marie-Paule Lefranc (France), Founding and Life Member 1989, Chair 1989
  • Fumihiko Matsuda(Japan), Founding and Life Member 1989, Deputy-Chair 2020

Acknowledgments to the Founding (1989) Honorary Members

  • Donald Capra (USA) (1937-2015)
  • Hans Georg Zachau (Germany) (1930-2017)

Publication for the 25 years of the Sub-Committee

Lefranc M.-P. Immunoglobulin (IG) and T cell receptor genes (TR): IMGT® and the birth and rise of immunoinformatics. Front Immunol. 2014 Feb 05;5:22. doi: 10.3389/fimmu.2014.00022. Open access PMID: 24600447 (on invitation of the IUIS Nomenclature Committee Chair)

IUIS NOM IMGT-NC Reports

Reports is an initiative of the IUIS Nomenclature Sub-Committee for immunoglobulins (IG), T cell receptors (TR) and major histocompatibility (MH) (IG/TR/MH), allowing scientists to submit IMGT names for new IG and TR variable (V), diversity (D), joining (J) and constant (C) genes and alleles to the IUIS Sub-Committee for approval, based on the IMGT Scientific chart rules and the IMGT-ONTOLOGY concepts of classification (CLASSIFICATION axiom).

Click on reports for submission procedure and report table.

You will find more information about the history of the Sub-Committee since its creation and all annual reports here:

IUIS NOM Immunoglobulins (IG), T cell Receptors (TR) and Major Histocompatibility (MH) Nomenclature Sub-Committee (IMGT-NC)

2021 Sub-Committee Report

Princeps References

1. Lefranc, M.-P. and Lefranc, G. The Immunoglobulin FactsBook, Academic Press, 458 pages (2001) ISBN: 012441351X eBook ISBN :9780080574479

The first published reference for all functional and ORF immunoglobulin (IG) genes. Introductory chapters present information on IG structural and biological properties, chain synthesis, gene chromosomal localization, and organization of the immunoglobulin heavy (IGH), kappa (IGK) and lambda (IGL) loci. This is followed by entries on 203 functional and ORF variable (V), diversity (D), joining (J) and constant (C) genes in Homo sapiens, and provides the first complete overview of the potential repertoire based on the IMGT Scientific chart rules (Locus representations, Alignments of alleles, Protein displays, IMGT Colliers de Perles).

2. Lefranc, M.-P. and Lefranc, G. The T cell receptor FactsBook, Academic Press, 398 pages (2001) ISBN: 0124413528 eBook ISBN :9780080542645

The first published reference for all functional and ORF T cell receptor (TR) genes. Introductory chapters present information on TR structural and biological properties, chain synthesis, gene chromosomal localization, and organization of the T cell receptor alpha (TRA), beta (TRB), gamma (TRG) and delta (TRD) loci. This is followed by entries on 168 functional and ORF variable (V), diversity (D), joining (J) and constant (C) genes in Homo sapiens, and provides the first complete overview of the potential repertoire based on the IMGT Scientific chart rules (Locus representations, Alignments of alleles, Protein displays, IMGT Colliers de Perles).

3. IMGT Locus in Focus (22 publications on IG and TR nomenclature published from 1998 to 2003, with pdf)

4. Lefranc, M.-P. WHO-IUIS Nomenclature Subcommittee for Immunoglobulins and T cell receptors report. Immunoglobulins and T cell receptors report August 2007, 13th International Congress of Immunology, Rio de Janeiro, Brazil. Dev. Comp. Immunol., 32, 461-463 (2008). Epub 2007 Nov6, doi:10.1016/j.dci.2007.09.008. PMID: 18036660  with permission from Elsevier LIGM:336

5. Lefranc, M.-P. WHO-IUIS Nomenclature Subcommittee for Immunoglobulins and T cell receptors report. Immunogenetics, 59, 899-902 (2007), Epub 2007 Nov29. doi: 10.1007/s00251-007-0260-4. PMID: 18046549 LIGM:334

6. Lefranc M.-P. and G. Lefranc. IMGT®Homo sapiens IG and TR loci, gene order, CNV and haplotypes: New concepts as a paradigm for jawed vertebrates genome assemblies. Biomolecules. 2022 Feb 28;12(3):381. doi: 10.3390/biom12030381. PMID: 35327572

An overview of the new concepts and requirements for submission of new IG and TR genes and alleles, from genome assemblies of Homo sapiens and other jawed vertebrates, to the IUIS NOM IMGT-NC Reports, and validation by the NOM Immunoglobulins (IG), T cell receptors (TR) and Major Histocompatibility (MH) Sub-Committee.